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Available from 11.1 What is network meta-analysis? Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Chapter 11: Undertaking network meta-analyses. Domain-specific assessments are combined to determine the overall confidence in the evidence.Ĭite this chapter as: Chaimani A, Caldwell DM, Li T, Higgins JPT, Salanti G. Grading confidence in evidence from a network meta-analysis begins by evaluating confidence in each direct comparison. direct and indirect) about a particular intervention comparison disagree. Incoherence (also called inconsistency) occurs when different sources of information (e.g. It also allows estimation of the ranking and hierarchy of interventions.Ī valid network meta-analysis relies on the assumption that the different sets of studies included in the analysis are similar, on average, in all important factors that may affect the relative effects.
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Network meta-analysis produces estimates of the relative effects between any pair of interventions in the network, and usually yields more precise estimates than a single direct or indirect estimate. Network meta-analysis is a technique for comparing three or more interventions simultaneously in a single analysis by combining both direct and indirect evidence across a network of studies.
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